Joining a critiqueing writers group is the single most important thing I've done to advance my writing career. A writers group without critiqueing is like a hospital without Doctors and Nurses. When your sick you need expert adviive on how to get well. The same goes for your manuscript. When it's sick, you need your writers group to first diaginois, and then prescribe treatment. Like you do with your doctor, you might not always heed this advice. Up to you.
The second is attending the Las Vegas Writers Conference in May of every year hosted by the Henderson Writers Group. this conference is unique in the fact that you get ten minutes face time with Agents and editors to pitch your work Trust me, you can do a lot in ten minutes.
More on the Henderson Writers Group and their conference to come